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Fig. 1 | Journal of Biomedical Science

Fig. 1

From: IL-8/CXCR1/2 signalling promotes tumor cell proliferation, invasion and vascular mimicry in glioblastoma

Fig. 1

Effect of IL-8 expression on immune cell infiltration. a Immunohistochemical expression of IL-8, CXCR1, and CXCR2 in FFPE tissues of GBM. Image resolution was × 200. Yellow arrows indicate staining in tumor cells. Red arrows indicate tumor vasculature which is showing positive staining only in CXCR1. b Stacked bar graph showing IHC score in GBM and Diffuse Astrocytoma (DA) in 48 cases each. Fisher’s exact test was used to analyse the statistical difference in immunohistochemical staining of IL-8, CXCR1 and CXCR2 between the two groups. *** indicates p < 0.001, NS=Non-significant. Total percentage positivity for individual protein in each group is given below each bar. c Immunohistochemical expression of CD68 and CD3 in FFPE tissues of GBM. The image resolution was at × 200 for CD68 and × 100 for CD3. d Stacked bar graph showing percentage positivity of IL-8, CD3, and CD68 in 48 GBM cases. Percentage positivity ranged between 0 and 50% in each group. Different colors in each bar graph represent the number of cases showing respective percentage positivity. r values indicate Pearson’s correlation coefficient calculated between IL-8 and CD3 and between IL-8 and CD68. The statistically significant positive correlation was observed between IL-8 and CD68. ** indicates p < 0.01

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