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Fig. 5 | Journal of Biomedical Science

Fig. 5

From: AXL phosphorylates and up-regulates TNS2 and its implications in IRS-1-associated metabolism in cancer cells

Fig. 5

Graphical abstract. Our results revealed a novel mechanism whereby Axl binds and phosphorylates TNS2 at Y483, releasing TNS2 from interacting with IRS-1, resulting in increased stability of IRS-1. Higher levels of IRS-1 may enhance cellular glucose uptake through up-regulation of Glut 4 and cell growth and survival. The two key enzymes of aerobic glycolysis, PDK1 was found to be up-regulated by the Axl/TNS2/IRS-1 cross-talk. The details of this regulatory cross-talk remain to be elucidated

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Journal of Biomedical Science

ISSN: 1423-0127