Table 2 The H. pylori virulence factors associated with gastric adenocarcinoma
From: The impacts of H. pylori virulence factors on the development of gastroduodenal diseases
Region | Virulence factor (High risk marker) | Odds ratio | Analytic method | Reference |
|---|---|---|---|---|
East Asia | CagL Y58E59 (vs. non-Y58E59) | 4.6 | DNA sequencing | [25] |
Bab AB BA recombination (vs. others) | 6.2 | PCR | [44] | |
Middle Asia | vacA i1 (vs. i2) | 10.9 | PCR | [34] |
Middle East | vacA s1 (vs. s2) | 4.0 | PCR | [36] |
vacA m1 (vs. m2) | 2.5 | PCR | [36] | |
vacA s1/m1 (vs. s2/m2) | 5.3 | PCR | [36] | |
vacA i1 (vs. i2) | 15.0 | PCR | [36] | |
Asia | EPIYA-D motif of CagA (vs. EPIYA-C) | 1.9 | DNA sequencing | [30] |
Western countries | Positive serum anti-CagA Ab | 2.0 | Serum ELISA | [19] |
cagA+ (vs. cagA-) | 2.4 | PCR or Immunoblot | [20] | |
≥ 2 copies of EPIYA-C motifs of CagA (vs. 1 copy) | 3.3 | DNA sequencing | [30] | |
Western EPIYA-B motif of CagA (vs. EPIYT-B) | 3.0 | DNA sequencing | [29] | |
vacA s1 (vs. s2) | 5.3 | PCR | [20] | |
vacA m1 (vs. m2) | 2.5 | PCR | [20] | |
vacA s1/m1 (vs. s2/m2) | 4.4 | PCR | [20] | |
BabA-L (vs. BabA-negative) | 33.9 | Immunoblot | [46] | |
BabA-H (vs. BabA-negative) | 18.2 | Immunoblot | [46] | |
oipA “on” (vs. oipA “off”) | 2.4 | DNA sequencing or immunoblot | [74] |