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Table 2 Regimens commonly used for H. pylori eradication

From: Toward population specific and personalized treatment of Helicobacter pylori infection

First-line Regimens

Dosing and frequencies

Clarithromycin triple therapy

A PPI bid, clarithromycin 500 mg bid, and amoxicillin 1 g bid or metronidazole 500 mg bid for 7–14 days

Bismuth quadruple therapy

A PPI bid, bismuth qid, tetracycline 500 mg qid, and metronidazole 500 mg tid for 7–14 days

Sequential therapy

A PPI bid plus amoxicillin 500 mg bid for 5–7 days, followed by a PPI bid plus clarithromycin 500 mg bid and metronidazole 500 mg bid for another 5–7 days

Concomitant therapy

A PPI bid plus amoxicillin 500 mg bid, clarithromycin 500 mg bid and metronidazole 500 mg bid for 7–14 days

Hybrid therapy

A PPI bid plus amoxicillin 500 mg bid for 5–7 days, followed by a PPI bid plus amoxicillin 500 mg bid, clarithromycin 500 mg bid and metronidazole 500 mg bid for another 5–7 days

Second-line/ third regimens

 Levofloxacin triple therapy

A PPI bid, levofloxacin 500 mg qd, and amoxicillin 1 g bid for 10–14 days

 Levofloxacin sequential therapy

A PPI bid plus amoxicillin 500 mg bid for 7 days, followed by a PPI bid plus levofloxacin 250 mg bid and metronidazole 500 mg bid for another 7 days

 Levofloxacin concomitant therapy

A PPI bid plus amoxicillin 500 mg bid, levofloxacin 250 mg bid and metronidazole 500 mg bid for 7–14 days

 Bismuth quadruple therapy

A PPI bid, bismuth qid, tetracycline 500 mg qid, and metronidazole 500 mg tid for 7–14 days

Fourth-line regimen

 Rifabutin triple therapy

A PPI bid, rifabutin 150 mg bid, and amoxicillin 1 g bid for 14 days

  1. Dosage of proton pump inhibitors (PPI): omeprazole 20 mg, lansoprazole 30 mg, esomeprazole 20 mg, pantoprazole 40 mg, rabeprazole 20 mg