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Table 4 Association study between CXCL12 rs1801157 and HPV in dominant model infection adjusted for confounder factors

From: Genetic variant in CXCL12 gene raises susceptibility to HPV infection and squamous intraepithelial lesions development: a case-control study

  Model 1 Model 2 Model 3 Model 4 Model 5 Model 6 Model 7
GG
 OR 1.00 1.00 1.00 1.00 1.00 1.00 1.00
 CI95% Reference Reference Reference Reference Reference Reference Reference
p value        
Allele A carrier
 OR 4.004 4.416 4.878 4.836 4.824 4.887 4.947
 CI95% (2.472–6.483) (2.677–7.284) (2.865–8.308) (2.819–8.296) (2.811–8.279) (2.829–8.442) (2.854–8.575)
p value < 0.001 < 0.001 < 0.001 < 0.001 < 0.001 < 0.001 < 0.001
  1. Logistic regression analysis with HPV as dependent variable (reference group = non-infected women) and CXCL12 rs1801157 polymorphism as explanatory variable, adjusted for several con- founders according to the proposed models (p < 0.05 as significance level). (SPSS Inc., Chicago, Illinois, USA). Significant p values are presented in bold
  2. Model 1: CXCL12 polymorphism adjusted for knowledge about HPV;
  3. Model 2: CXCL12 polymorphism adjusted for knowledge about HPV and age;
  4. Model 3: CXCL12 polymorphism adjusted for knowledge about HPV, age and monthly income;
  5. Model 4: CXCL12 polymorphism adjusted for knowledge about HPV, age, monthly income and smoking status;
  6. Model 5: CXCL12 polymorphism adjusted for knowledge about HPV, age, monthly income, smoking status and number of pregnancies;
  7. Model 6: CXCL12 polymorphism adjusted for knowledge about HPV, age, monthly income, smoking status, number of pregnancies, and number of sexual partners;
  8. Model 7: CXCL12 polymorphism adjusted for knowledge about HPV, age, monthly income, smoking status, number of pregnancies, number of sexual partners and marital status