Table 1 Potential involvement of TRAX-interacting proteins in three psychiatric disorders
From: The TRAX, DISC1, and GSK3 complex in mental disorders and therapeutic interventions
Binding partner | Full name | Gene name | Schizophrenia | Autism | Panic attack |
|---|---|---|---|---|---|
A2A adenosine receptor | ADORA2A | Risk gene (#) | Risk gene [167] | ||
Akap9 [168] | A-kinase anchoring protein 9 | AKAP9 | Risk gene [167] | ||
ATM [137] | Ataxia telangiectasia mutated | ATM | – | – | |
C1D [136] | nuclear matrix protein C1D | C1D | (1) Risk gene (*) | – | – |
(2) Drug target [175] | |||||
DISC1 [5] | Disrupted in schizophrenia 1 | DISC1 | (1) Risk gene (*) | Risk gene [167] | |
GSK3β [5] | Glycogen Synthase Kinase 3 Beta | GSK3B | (1) Risk gene (*) | Risk gene [181] | |
(2) Drug target [182] | |||||
Kinesin Family Member 2A | KIF2A | Risk gene (*) | – | – | |
MEA2 [168] | Male-enhanced antigen 2 | MEA2 | – | – | – |
Phospholipase C Beta 1 | PLCB1 | Risk gene (#, [188]) | – | ||
SUN1 [168] | SUN domain-containing protein 1 | SUN1 | – | – | – |
Translin | TSN | Risk gene (#, [193]) | – | ||
TRAX-interacting protein-1 [22] | Translin Associated Factor X Interacting Protein 1 | TSNAXIP1 | Risk gene [194] | – | – |