Novel mutation G324C in WNT1 mapped in a large Pakistani family with severe recessively inherited Osteogenesis Imperfecta

Table 1 Summary of residues involved in WNT1 docking interactions (Wild & Mutant)

Receptor/Ligand	Hydrogen Bond Interactions		Hydrophobic Bond Interactions
Receptor/Ligand	Ligand Residues	Receptor Residues	Ligand Residues	Receptor Residues
Wild WNT1-Axin 1	Val383, Glu391, Arg395, Val399, Gln400	Arg98, Cys218, Arg344, Cys347, Cys352	Glu384, Pro385, Phe388, Ala389, Leu392, Leu396, Arg401	Arg215, Gln216, Glu217, Arg235, Thr238, Arg240, Asp244, Arg247, Pro320, Thr348, Phe349, His350, Val355
Mutated WNT1-Axin 1	Gln386, Phe388, Glu390, Leu396, Glu397, Gln400	Lys51, Trp95, Arg98, Arg337, Glu368	Val383, Glu391, Leu392, Val399	Asn29, Ser50, Arg91, Lys94, Gly312, Arg335

ISSN: 1423-0127