Fig. 2
From: A novel ligand-receptor relationship between families of ribonucleases and receptor tyrosine kinases
A proposed model of the ligand-receptor cognate signaling through a ligand-like function of RNases. The human RNase A superfamily contains 13 known members that are divided into canonical (RNases 1–8) and non-canonical (RNases 9–13) subgroups. The fifth member of the RNase A superfamily, hRNase5/ANG, functions as an EGFR ligand. Identification of the hRNase5/ANG-EGFR axis raises an interesting question of whether other RNase family members may play a ligand-like function, linking the two unrelated protein families, namely RNases and RTKs or non-RTK cell surface receptors. Red stars indicate receptor activation. The scale of the diagram does not reflect the relative sizes of different molecules