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Table 1 Summary of characteristics of RNases

From: A novel ligand-receptor relationship between families of ribonucleases and receptor tyrosine kinases

RNase Species Subgroup Chromosome Predicted mass (kDa)b Isoelectric points (pI) RNase activityc
bRNaseA bovine 13.7 9.3 [2]
hRNase1 human canonical 14q11.2 17.6 8.6 [22] 0.147
hRNase2/EDNa human canonical 14q11.2 18.4 8.9 [22] 0.65
hRNase3/ECPa human canonical 14q11.2 18.4 11.4 [22] 0.048
hRNase4 human canonical 14q11.2 16.8 8.9 [22] ~hRNase1
hRNase5/ANGa human canonical 14q11.2 16.6 10.4 [22] extremely low
hRNase6/k6 human canonical 14q11.2 17.2 9.1 [22] 0.034
hRNase7 human canonical 14q11.2 17.4 10.5 [22] 0.021
hRNase8 human canonical 14q11.2 17.0 8.2 [22] 0.012
hRNase9 human non-canonical 14q11.2 24.3 n/a inactive
hRNase10 human non-canonical 14q11.2 24.0 n/a inactive
hRNase11 human non-canonical 14q11.2 22.4 n/a inactive
hRNase12 human non-canonical 14q11.2 17.2 n/a inactive
hRNase13 human non-canonical 14q11.2 17.8 n/a inactive
  1. aEDN eosinophil-derived neurotoxin, ECP eosinophil cationic protein, ANG angiogenin
  2. bSummary of hRNases from Uniprot (www.uniprot.org/uniprot/)
  3. cRNase activity was measured against yeast tRNA as per pmol RNA substrate digested/pmol enzyme/sec [22, 36]