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Table 2 Summary of tissue specificity and biological process of RNases

From: A novel ligand-receptor relationship between families of ribonucleases and receptor tyrosine kinases

RNase Main expression tissues/cellsa Biological processes b
hRNase1 • Pancreas
• Gastrointestinal tract
• Male tissues
• Brain
• Appendix
• Kidney
• Endothelial cells
• Ribonucleolytic activity
• Coagulation and inflammation [195]
hRNase2/EDN • Bone marrow
• Spleen
• Liver
• Lung
• Eosinophils
• Neutrophils
• Monocytes
• Ribonucleolytic activity
• Antiviral activity
• Chemotactic activity
• Neutrophil degranulation
hRNase3/ECP • Bone marrow
• Eosinophils
• Neutrophils
• Monocytes
• T cells
• Ribonucleolytic activity
• Antibacterial activity
• Antiviral activity
• Cytotoxic to mammalian cells
• Neutrophil degranulation
• Innate immune response
hRNase4 • Liver
• Adipose
• Colon
• Monocytes
• B cells /T cells
• Endothelial cells
• Ribonucleolytic activity
• Protection of neuron degeneration
hRNase5/ANG • Liver
• Spinal cord neurons
• T cells
• Mast cells
• Endothelial cells
• EGFR ligand [46]
• Hematopoietic regeneration [81]
• Binding to plexin-B2 receptor [101]
• Tumorigenesis
• Weak ribonucleolytic activity
• Neuroprotection
• Antibacterial activity
• Antifungal activity
• Angiogenesis
• Ribosomal RNA transcription
• Innate immune response
hRNase6/k6 • Bone marrow
• Tonsil
• Lung
• Thymus
• Monocytes
• Neutrophils
• Ribonucleolytic activity
• Antibacterial activity
• Antimicrobial activity
• Antiviral activity
• Innate immune response
hRNase7 • Skin
• Tonsil
• Female tissues
• Gastrointestinal tract
• Kidney
• Liver
• Skeletal muscle
• Heart
• Ribonucleolytic activity
• Antimicrobial activity
• Antibacterial activity
• Antifungal activity
• Innate immune response
• Membrane disruption in other organism
hRNase8 • Placenta
• Spleen
• Lung
• Testis
• Ribonucleolytic activity
• Antimicrobial activity
• Antibacterial activity
• Antifungal activity
• Innate immune response
hRNase9 • Male tissues • Male reproductive functions [4, 196]
• Antibacterial activity [35]
hRNase10 • Male tissues
• Heart
• Male reproductive functions [4, 196]
• Regulation of cell-cell adhesion
hRNase11 • Male tissues • Male reproductive functions [4, 196]
hRNase12 • Male tissues • Male reproductive functions [4, 196]
hRNase13 • Male tissues • Male reproductive functions [4, 196]
  1. a Summary from [196], Uniprot (www.uniprot.org/uniprot/), and The Human Protein Atlas (https://www.proteinatlas.org/)
  2. b Summary from Uniprot (www.uniprot.org/uniprot/)