Table 2 Summary of tissue specificity and biological process of RNases

hRNase1

• Pancreas

• Gastrointestinal tract

• Male tissues

• Brain

• Appendix

• Kidney

• Endothelial cells

• Ribonucleolytic activity

• Coagulation and inflammation [195]

hRNase2/EDN

• Bone marrow

• Spleen

• Liver

• Lung

• Eosinophils

• Neutrophils

• Monocytes

• Ribonucleolytic activity

• Antiviral activity

• Chemotactic activity

• Neutrophil degranulation

hRNase3/ECP

• Bone marrow

• Eosinophils

• Neutrophils

• Monocytes

• T cells

• Ribonucleolytic activity

• Antibacterial activity

• Antiviral activity

• Cytotoxic to mammalian cells

• Neutrophil degranulation

• Innate immune response

hRNase4

• Liver

• Adipose

• Colon

• Monocytes

• B cells /T cells

• Endothelial cells

• Ribonucleolytic activity

• Protection of neuron degeneration

hRNase5/ANG

• Liver

• Spinal cord neurons

• T cells

• Mast cells

• Endothelial cells

• EGFR ligand [46]

• Hematopoietic regeneration [81]

• Binding to plexin-B2 receptor [101]

• Tumorigenesis

• Weak ribonucleolytic activity

• Neuroprotection

• Antibacterial activity

• Antifungal activity

• Angiogenesis

• Ribosomal RNA transcription

• Innate immune response

hRNase6/k6

• Bone marrow

• Tonsil

• Lung

• Thymus

• Monocytes

• Neutrophils

• Ribonucleolytic activity

• Antibacterial activity

• Antimicrobial activity

• Antiviral activity

• Innate immune response

hRNase7

• Skin

• Tonsil

• Female tissues

• Gastrointestinal tract

• Kidney

• Liver

• Skeletal muscle

• Heart

• Ribonucleolytic activity

• Antimicrobial activity

• Antibacterial activity

• Antifungal activity

• Innate immune response

• Membrane disruption in other organism

hRNase8

• Placenta

• Spleen

• Lung

• Testis

• Ribonucleolytic activity

• Antimicrobial activity

• Antibacterial activity

• Antifungal activity

• Innate immune response

hRNase9

• Male tissues

• Male reproductive functions [4, 196]

• Antibacterial activity [35]

hRNase10

• Male tissues

• Heart

• Male reproductive functions [4, 196]

• Regulation of cell-cell adhesion

hRNase11

• Male tissues

• Male reproductive functions [4, 196]

hRNase12

• Male tissues

• Male reproductive functions [4, 196]

hRNase13

• Male tissues

• Male reproductive functions [4, 196]