A novel ligand-receptor relationship between families of ribonucleases and receptor tyrosine kinases

Table 3 Summary of EGFR ligands

EGFR ligand	Predicted mass (kDa)	Binding affinity (Kd)	Group	Reference
EGF^a	6.2	0.6 nM; 1.8 nM	high	[46, 143, 145]
BTC	9.8	1.4 nM	high	[143, 145]
HB-EGF	9.7	7.1 nM	high	[143, 145]
TGFα	5.6	9.2 nM	high	[143, 145]
hRNase5/ANG	16.6	41.6 nM	high	[46]
AREG^a	11	217.4 nM; 350 nM	low	[46, 145]
EREG	5.6	100-fold lower than EGF	low	[143, 197]
EREG^b	5.5	2.8 μM	low	[145]
EPGN	7.9	> 500 nM	low	[145]
bRNaseA^c	13.7	885.3 nM	low	[46]

ISSN: 1423-0127