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Table 3 Summary of EGFR ligands

From: A novel ligand-receptor relationship between families of ribonucleases and receptor tyrosine kinases

EGFR ligand Predicted mass (kDa) Binding affinity (Kd) Group Reference
EGFa 6.2 0.6 nM; 1.8 nM high [46, 143, 145]
BTC 9.8 1.4 nM high [143, 145]
HB-EGF 9.7 7.1 nM high [143, 145]
TGFα 5.6 9.2 nM high [143, 145]
hRNase5/ANG 16.6 41.6 nM high [46]
AREGa 11 217.4 nM; 350 nM low [46, 145]
EREG 5.6 100-fold lower than EGF low [143, 197]
EREGb 5.5 2.8 μM low [145]
EPGN 7.9 > 500 nM low [145]
bRNaseAc 13.7 885.3 nM low [46]
  1. aKd values from two independent reports
  2. bmurine epiregulin
  3. cbovine RNase A