Table 3 Summary of EGFR ligands
From: A novel ligand-receptor relationship between families of ribonucleases and receptor tyrosine kinases
| EGFR ligand | Predicted mass (kDa) | Binding affinity (Kd) | Group | Reference |
|---|---|---|---|---|
| EGFa | 6.2 | 0.6 nM; 1.8 nM | high | [46, 143, 145] |
| BTC | 9.8 | 1.4 nM | high | [143, 145] |
| HB-EGF | 9.7 | 7.1 nM | high | [143, 145] |
| TGFα | 5.6 | 9.2 nM | high | [143, 145] |
| hRNase5/ANG | 16.6 | 41.6 nM | high | [46] |
| AREGa | 11 | 217.4 nM; 350 nM | low | [46, 145] |
| EREG | 5.6 | 100-fold lower than EGF | low | [143, 197] |
| EREGb | 5.5 | 2.8 μM | low | [145] |
| EPGN | 7.9 | > 500 nM | low | [145] |
| bRNaseAc | 13.7 | 885.3 nM | low | [46] |