Table 1 Types of tissue acidosis and associated pain

Ischemia

Brain

Stroke

6.2~ 7.0 (Rat)

Central post-stroke pain

[47]

Brain

Intracranial hypertension

~ 7.05

Headache and widespread pain

[48, 49]

Heart

Angina

6.9~ 7.0 (Cat)

Chest pain

[4]

Intestine

Small bowel obstruction

6.8~ 7.1

Abdominal pain

[50]

Lower limbs

Peripheral artery disease

< 7.15 (Cat)

Pain

[51]

Muscle

Tourniquet test

~ 7.0

Muscle pain

[9]

Vessel

Sickle cell disease

< 7.36

Sickle pain

[52, 53]

Injury

Skin

Surgery

6.9~ 7.1 (Rat)

Postoperative pain

[5]

Muscle

Surgery

6.5~ 7.1 (Rat)

Postoperative pain

[5]

Inflammation

Joint

Osteoarthritis

6.9~ 7.4 (Rabbit)

Pain

[54]

Joint

Rheumatoid arthritis

7.1~ 7.4

~ 6.2 (Mouse)

Pain

[34]

[3]

Skin

Skin wound

7.0~ 7.3 (Rabbit)

Dermal pain

[55]

Blood

Sepsis

7.2~ 7.3

Pain/Soreness

[56]

Muscle

Flu

NA

Pain/soreness

[57]

Fatiguing exercise

Muscle

Delayed onset muscle soreness

6.6~ 6.9 (Mouse)

Soreness

[2]

Metabolism disorders

Blood

Diabetic ketoacidosis

≤ 6.9 ~  7.2

Abdominal pain

[58]

Blood

Renal tubular acidosis

~ 7.2

Widespread muscle & joint pain

[59]

Tumor

Bone

Bone cancer

4.0~ 6.0 (Mouse)

Cancer pain

[60]