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Table 1 Types of tissue acidosis and associated pain

From: Sensing acidosis: nociception or sngception?

Conditions Affected sites Examples pH ranges (in animal models) Pain/soreness References
Ischemia Brain Stroke 6.2~ 7.0 (Rat) Central post-stroke pain [47]
Brain Intracranial hypertension ~ 7.05 Headache and widespread pain [48, 49]
Heart Angina 6.9~ 7.0 (Cat) Chest pain [4]
Intestine Small bowel obstruction 6.8~ 7.1 Abdominal pain [50]
Lower limbs Peripheral artery disease < 7.15 (Cat) Pain [51]
Muscle Tourniquet test ~ 7.0 Muscle pain [9]
Vessel Sickle cell disease < 7.36 Sickle pain [52, 53]
Injury Skin Surgery 6.9~ 7.1 (Rat) Postoperative pain [5]
Muscle Surgery 6.5~ 7.1 (Rat) Postoperative pain [5]
Inflammation Joint Osteoarthritis 6.9~ 7.4 (Rabbit) Pain [54]
Joint Rheumatoid arthritis 7.1~ 7.4
~ 6.2 (Mouse)
Pain [34]
[3]
Skin Skin wound 7.0~ 7.3 (Rabbit) Dermal pain [55]
Blood Sepsis 7.2~ 7.3 Pain/Soreness [56]
Muscle Flu NA Pain/soreness [57]
Fatiguing exercise Muscle Delayed onset muscle soreness 6.6~ 6.9 (Mouse) Soreness [2]
Metabolism disorders Blood Diabetic ketoacidosis ≤ 6.9 ~  7.2 Abdominal pain [58]
Blood Renal tubular acidosis ~ 7.2 Widespread muscle & joint pain [59]
Tumor Bone Bone cancer 4.0~ 6.0 (Mouse) Cancer pain [60]
  1. NA: not available