Fig. 3

New classification based on orthologue analysis of 218 ICEHptfs genomes adapted from Delahay et al. [25]. a The modular subtype of ICEHptfs4. The modular subtype was classified based on three regions: left flank (L1/L2/Lm), central region (C1/C2), and right flank (R1/R2/R1f). The green arrow corresponds to the conserved region, whereas the blue and red arrows correspond to the type 1 (L1-C1-R1/R1f) and type 2 (L2-C2-R2) modules, respectively. The Lm was described as a combination between L1 and L2 on the left flank region. b The modular type of ICEHptfs3. Unlike ICEHptfs4, which had a subtype, ICEHptfs3 is conserved in almost ICEHptfs3-containing strains with the classification based on the presence/absence of the left segment and the right segment of this region