Table 2 The main synthetic polymers used in neural tissue engineering, biocompatibility in vitro/in vivo, and examples of their applications
From: Current and novel polymeric biomaterials for neural tissue engineering
| Synthetic Polymer | Biocompatibility in vitro | Biocompatibility in vivo | Application | References |
|---|---|---|---|---|
| Preclinical Studies | ||||
| PLA | Rat SCs | Nanofibrous conduit | [159] | |
| NSCs | Nanofibrous conduit | [162, 163] | ||
| PLGA | U87 | Microparticles | [36] | |
| Dogs | Nerve conduit | [122] | ||
| DRGs | Rats | Scaffold | [164] | |
| Rats | Microparticles | [166] | ||
| PEG | NPCs | Hydrogel | [169,170,171] | |
| Rats | Hydrogel | [171] | ||
| Rats | Intravenous administration | [172, 173] | ||
| Guinea pig spinal cord injury model | pure PEG | [174] | ||
| Rats | Scaffold | [175] | ||
| pHEMA | Rats | Hydrophilic sponge | [176] | |
| PC12 | Hydrogel | [179] | ||
