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Table 2 The main synthetic polymers used in neural tissue engineering, biocompatibility in vitro/in vivo, and examples of their applications

From: Current and novel polymeric biomaterials for neural tissue engineering

Synthetic Polymer Biocompatibility in vitro Biocompatibility in vivo Application References
Preclinical Studies
 PLA Rat SCs   Nanofibrous conduit [159]
NSCs   Nanofibrous conduit [162, 163]
 PLGA U87   Microparticles [36]
  Dogs Nerve conduit [122]
DRGs Rats Scaffold [164]
  Rats Microparticles [166]
 PEG NPCs   Hydrogel [169,170,171]
  Rats Hydrogel [171]
  Rats Intravenous administration [172, 173]
Guinea pig spinal cord injury model   pure PEG [174]
  Rats Scaffold [175]
 pHEMA   Rats Hydrophilic sponge [176]
PC12   Hydrogel [179]
  1. PLA: polylactic acid; PLGA: poly(lactic-co-glycolic acid); PEG: polyethylene glycol; pHEMA: poly(2-hydroxyethylmethacrylate); SCs: stem cells; NSCs: neural stem cells; DRGs: dorsal root ganglia; NPCs: neural progenitor cells.