Current and novel polymeric biomaterials for neural tissue engineering

Table 3 The main electroconductive polymers used in neural tissue engineering, biocompatibility in vitro/in vivo, and examples of their applications

Electroconductive Polymer	Biocompatibility in vitro	Biocompatibility in vivo	Application	References
Preclinical Studies
PPy	PC12		Electrospun nanofibers	[19, 182]
	PC12	Rats	Films	[20]
	PC12	Rats	Nerve conduit	[183, 184]
	hNSCs	Rats	Hydrogel	185, 186]
	PC12		Electrodes	[187]
	Auditory neurons from Albino-Wistar rats		Electrodes	[188]
	Primary murine cerebellar glial culture		Vehicle for drug delivery	[190]
	PC12		Vehicle for drug delivery	[154]
		Rats	Vehicle for drug delivery	[191]
PANi	PC12		Electrospun nanofibres	[193]
		Rats	Nerve conduit	[38, 194]
	NSCs		Hydrogel	[195]
	PC12		Hydrogel	[31]
		Rats	Electronic patch	[196]
PEDOT		Rats	Electrodes	[197, 198]
		Mice	Electrodes	[46]
	Neurons from E18 Sprague- Dawley cortices		Electrodes	[199]
		Rats	Electrodes	[200, 201]
	ReNcell VM		Substrate	[202]
	P19		Substrate	[203]
InP	Primary cell cultures from hippocampal regions of rats		Nanowire scaffolds	[204]

PPy: polypyrrole; PANi: polyaniline; PEDOT: Poly (3,4-ethylenedioxythiopene); InP: indium phosphide; hNSCs: human neural stem cells; NSCs: neural stem cells.

ISSN: 1423-0127