Table 3 The main electroconductive polymers used in neural tissue engineering, biocompatibility in vitro/in vivo, and examples of their applications
From: Current and novel polymeric biomaterials for neural tissue engineering
| Electroconductive Polymer | Biocompatibility in vitro | Biocompatibility in vivo | Application | References |
|---|---|---|---|---|
| Preclinical Studies | ||||
| PPy | PC12 | Electrospun nanofibers | [19, 182] | |
| PC12 | Rats | Films | [20] | |
| PC12 | Rats | Nerve conduit | [183, 184] | |
| hNSCs | Rats | Hydrogel | 185, 186] | |
| PC12 | Electrodes | [187] | ||
| Auditory neurons from Albino-Wistar rats | Electrodes | [188] | ||
| Primary murine cerebellar glial culture | Vehicle for drug delivery | [190] | ||
| PC12 | Vehicle for drug delivery | [154] | ||
| Rats | Vehicle for drug delivery | [191] | ||
| PANi | PC12 | Electrospun nanofibres | [193] | |
| Rats | Nerve conduit | [38, 194] | ||
| NSCs | Hydrogel | [195] | ||
| PC12 | Hydrogel | [31] | ||
| Rats | Electronic patch | [196] | ||
| PEDOT | Rats | Electrodes | [197, 198] | |
| Mice | Electrodes | [46] | ||
| Neurons from E18 Sprague- Dawley cortices | Electrodes | [199] | ||
| Rats | Electrodes | [200, 201] | ||
| ReNcell VM | Substrate | [202] | ||
| P19 | Substrate | [203] | ||
| InP | Primary cell cultures from hippocampal regions of rats | Nanowire scaffolds | [204] | |
