Emerging roles of gap junction proteins connexins in cancer metastasis, chemoresistance and clinical application

Table 1 Cx43 expression in clinical samples and its correlation with patients’ clinical outcomes

Cancer Type	Clinical manifest	Ref.
Cx43 in primary tumor tissues
Gastric	Cytoplasmic Cx43; reversely correlated with lymph node metastasis	[19]
Pancreatic	Cytoplasmic Cx43; reversely correlated with lymph node metastasis	[36]
NSCLC	Cytoplasmic Cx43; reversely correlated with lymph node metastasis	[33, 37]
Laryngeal cancer	Cell surface Cx43; reversely correlated with lymph node metastasis, 5-year overall survival, and recurrence	[38, 39]
Cx43 in metastatic lesions
Breast	Cell surface Cx43; increased expression and membrane localization in lymph node metastases	[18]
Melanoma	Cx43 mRNA; elevated expression in metastatic tissues	[34]
Gastric	Cx43 mRNA; elevated expression in metastatic peritoneal tissues	[29]
Breast	Cx43 mRNA; elevated expression in metastatic tissues	[43,44,45]

ISSN: 1423-0127