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Table 1 Cx43 expression in clinical samples and its correlation with patients’ clinical outcomes

From: Emerging roles of gap junction proteins connexins in cancer metastasis, chemoresistance and clinical application

Cancer Type Clinical manifest Ref.
Cx43 in primary tumor tissues
 Gastric Cytoplasmic Cx43; reversely correlated with lymph node metastasis [19]
 Pancreatic Cytoplasmic Cx43; reversely correlated with lymph node metastasis [36]
 NSCLC Cytoplasmic Cx43; reversely correlated with lymph node metastasis [33, 37]
 Laryngeal cancer Cell surface Cx43; reversely correlated with lymph node metastasis, 5-year overall survival, and recurrence [38, 39]
Cx43 in metastatic lesions
 Breast Cell surface Cx43; increased expression and membrane localization in lymph node metastases [18]
 Melanoma Cx43 mRNA; elevated expression in metastatic tissues [34]
 Gastric Cx43 mRNA; elevated expression in metastatic peritoneal tissues [29]
 Breast Cx43 mRNA; elevated expression in metastatic tissues [43,44,45]
  1. NSCLC Non-small cell lung cancer