Fig. 1

The amino acid sequences of HtrA among 26,695 and 10 clinical isolates are listed, including 5 NUD isolates (NUD-Hp0023, NUD-Hp0045, NUD-Hp0560, NUD-Hp0606, NUD-Hp0608), and 5 GC isolates (GC-Hp0268, GC-Hp0779, GC-Hp0876, GC-Hp1030, GC-Hp-1033). The “*” indicates the active residues 81, 164, 165, 166, 168, 208, 221, 260 and 328 (according to HtrA sequence from NCBI, residue 81, 164, 165, 166, 168, 208, 221, 260 and 328 should be residue 82, 165, 166, 167, 169, 209, 222, 261 and 329, respectively), and the “#” indicates sequences with variations at the residue 171