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Table 1 The polymorphisms of HtrA amino acid sequence among isolate from patients with different clinical diagnosis

From: H. pylori isolates with amino acid sequence polymorphisms as presence of both HtrA-L171 & CagL-Y58/E59 increase the risk of gastric cancer

Residue n (%)

NUD (n = 71)

PU (n = 63)

GC (n = 30)

P value a OR (95% CI)

P value b OR (95% CI)

6 F

40 (56.3)

39 (61.9)

19 (63.3)

0.513

1.3 (0.6–2.5)

0.515

1.3 (0.6–3.2)

25 N

20 (28.2)

16 (25.4)

11 (36.7)

0.718

0.9 (0.4–1.9)

0.397

1.5 (0.6–3.6)

68 S

11 (15.5)

9 (14.3)

8 (26.7)

0.845

0.9 (0.4–2.4)

0.189

2.0 (0.7–5.6)

171 L

36 (50.7)

38 (60.3)

22 (73.3)

0.264

1.5 (0.7–2.9)

0.036

2.7 (1.1–6.8)

303 V

52 (73.2)

48 (76.2)

24 (80.0)

0.695

1.2 (0.5–2.6)

0.472

1.5 (0.5–4.1)

312 A

44 (62.0)

39 (61.9)

19 (63.3)

0.994

1.0 (0.5–2.0)

0.897

1.1 (0.4–2.6)

382 T

16 (22.5)

11 (17.5)

9 (30.0)

0.465

0.7 (0.3–1.7)

0.427

1.5 (0.6–3.8)

  1. Abbreviations: NUD non-ulcer dyspepsia, PU peptic ulcer, GC gastric cancer, OR odds ratio, 95% CI 95% confidence interval. The P value was determined by χ2 test. a indicated significance with P < 0.05 of such parameter between NUD and PU; b between NUD and GC