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Table 1 The polymorphisms of HtrA amino acid sequence among isolate from patients with different clinical diagnosis

From: H. pylori isolates with amino acid sequence polymorphisms as presence of both HtrA-L171 & CagL-Y58/E59 increase the risk of gastric cancer

Residue n (%) NUD (n = 71) PU (n = 63) GC (n = 30) P value a OR (95% CI) P value b OR (95% CI)
6 F 40 (56.3) 39 (61.9) 19 (63.3) 0.513 1.3 (0.6–2.5) 0.515 1.3 (0.6–3.2)
25 N 20 (28.2) 16 (25.4) 11 (36.7) 0.718 0.9 (0.4–1.9) 0.397 1.5 (0.6–3.6)
68 S 11 (15.5) 9 (14.3) 8 (26.7) 0.845 0.9 (0.4–2.4) 0.189 2.0 (0.7–5.6)
171 L 36 (50.7) 38 (60.3) 22 (73.3) 0.264 1.5 (0.7–2.9) 0.036 2.7 (1.1–6.8)
303 V 52 (73.2) 48 (76.2) 24 (80.0) 0.695 1.2 (0.5–2.6) 0.472 1.5 (0.5–4.1)
312 A 44 (62.0) 39 (61.9) 19 (63.3) 0.994 1.0 (0.5–2.0) 0.897 1.1 (0.4–2.6)
382 T 16 (22.5) 11 (17.5) 9 (30.0) 0.465 0.7 (0.3–1.7) 0.427 1.5 (0.6–3.8)
  1. Abbreviations: NUD non-ulcer dyspepsia, PU peptic ulcer, GC gastric cancer, OR odds ratio, 95% CI 95% confidence interval. The P value was determined by χ2 test. a indicated significance with P < 0.05 of such parameter between NUD and PU; b between NUD and GC