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Table 3 The comparison of histopathology among NUD subjects with different status of HtrA-L171 & CagL-Y58/E59 of H. pylori infection

From: H. pylori isolates with amino acid sequence polymorphisms as presence of both HtrA-L171 & CagL-Y58/E59 increase the risk of gastric cancer

Histology score, mean (SD) HtrA-L171 & CagL-Y58/E59 status P value
Both absence (n = 27) HtrA-171 L alone (n = 28) CagL-Y58/E59 alone (n = 6) Both presence (n = 7)
Antrum
 AIS 1.44 (0.97) 1.64 (0.78) 1.33 (1.03) 1.29 (0.95) NS
 CIS 2.74 (0.53) 2.96 (0.19) 2.67 (0.82) 2.71 (0.49) 0.039a; 0.037b
 HPD 3.26 (1.26) 3.36 (1.19) 3.17 (1.72) 3.86 (1.07) NS
Corpus
 AIS 1.00 (0.96) 0.93 (0.98) 1.17 (0.98) 0.57 (0.98) NS
 CIS 2.37 (0.79) 2.32 (0.82) 2.83 (0.41) 2.14 (0.07) NS
 HPD 3.41 (1.37) 3.46 (1.17) 3.67 (1.03) 2.43 (1.62) NS
  1. Abbreviations: AIS acute inflammation score (range 0–3), CIS chronic inflammation score (range 1–3); HPD, H. pylori density (range 0–5). Statistical analysis was performed by Mann-Whitney U test. a indicated significance with P < 0.05 of such parameter between both absence and HtrA-L171 alone H. pylori infection; b between HtrA-L171 alone and both presence. NS: no significant difference