Cross-talk between cancer cells and their neighbors via miRNA in extracellular vesicles: an emerging player in cancer metastasis

Table 1 Function of miRNAs in EVs in cancer metastasis

Phenotype	Donor Cells	Recipient Cells	miRNA	Target Gene of miRNA	Reference
Induction of angiogenesis	Breast cancer cell		miR-210	–	[41]
	HCC cell	EC	miR-210	SMAD4 and STAT6	[42]
	Melanoma cell		miR-9	SOCS5	[43]
Destruction of endothelial barriers	Breast cancer cell	EC	miR-105	ZO-1	[44]
Breakdown of blood-brain barrier	Breast cancer cell	EC	miR-181c	PDPK1	[45]
Treg expansion	Lewis lung carcinoma	CD4 + T cell	miR-214	PTEN	[49]
Promotion of inflammation	Lung cancer cell	Macrophage	miR-21 and -29a	TLR	[50]
Promoting invasion	TAM	Breast cancer cell	miR-233	Mef2s	[51]
TAM transition	Colorectal cancer	Monocyte	miR-203	–	[52]
Dysfunction of DC	Pancreatic cancer	DC	miR-203	TLR4	[53]
Immune tolerance of DC	Pancreatic cancer	DC	miR-212	RFXAP	[54]
Up-regulation matrix metalloproteinases	Pancreatic adenocarcinoma	Fibroblast	miR-494 and − 542-3p	Cadherin-17, MAL and TRAF4	[57]
CAF transition	HCC cell	Fibroblast	miR-1247-3p	B4GALT3	[59]
Induction of EMT	CAF	Prostate cancer cell	miR-409	RSU1 and STAG2	[60]
Induction of EMT	CAF	Breast cancer cell	miR-21, −278e, and − 143	–	[61]
Inhibition of apoptosis and induction of drug resistance	CAF	Ovarian cancer cell	miR-21	APAF1	[62]
Reduction of glucose uptake	Breast cancer cell	Fibroblast	miR-122	Pyruvate kinase	[63]
Suppression of proliferation	Bone stromal cell	Breast cancer cell	miR-127, −197, −222 and − 223	CXCL12	[64]
Induction of dormancy	BM-MSC	Breast cancer cell	miR-23b	MARCKS	[65]
Induction of dormancy and drug resistance	BM-MSC	Breast cancer cell	miR-222 and − 223	–	[66]

Foot Note: miRNA microRNA, HCC hepatocellular carcinoma, TAM tumor-associated macrophage, CAF cancer-associated fibroblast, BM bone marrow, MSC mesenchymal stem cell, EC endothelial cells, DC dendritic cell, SOCS5 suppressor of cytokine signaling 5, ZO-1 zonula occludens protein 1, PDPK1 phosphoinositide-dependent protein kinase-1, PTEN phosphatase and tensin homolog, TLR Toll-like receptor, RFXAP regulatory factor X-associated protein, Mef2c myocyte enhancer factor 2c, Treg regulatory T cell

ISSN: 1423-0127