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Fig. 6 | Journal of Biomedical Science

Fig. 6

From: Brazilian strains of Toxoplasma gondii are controlled by azithromycin and modulate cytokine production in human placental explants

Fig. 6

TGF-β production by human villous explants infected with RH, ME49 or TgChBrUD1 (UD1) or TgChBrUD2 (UD2) strain and treated with (a) azithromycin (1000 μg/mL) (AZ), (b) spiramycin (ESP) (1000 μg/mL) or (c) pyrimethamine (200 μg/mL) and sulfadiazine (150 μg/mL) (PS). As a control, villous explants were only infected with RH, ME49, UD1 or UD2 (Untreated). Supernatants were collected after 24 h of infection and the production of MIF was measured by sandwich ELISA. Four placentas were used and four independent experiments were performed at least in duplicate. *Comparison between infected villous explants and infected treated villous explants (Student’s t test, mean ± standard error of the mean (SEM), P < 0.05; $Comparison in relation to ME49-infected/treated villous explants; &Comparison in relation to UD1-infected/treated villous explants (ANOVA and Newman-Keuls multiple comparison test, mean ± standard error of the mean (SEM), P < 0.05)

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