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Fig. 7 | Journal of Biomedical Science

Fig. 7

From: Aberrant methylation and downregulation of ZNF667-AS1 and ZNF667 promote the malignant progression of laryngeal squamous cell carcinoma

Fig. 7

The regulation mechanism of ZNF667-AS1 and ZNF667. a. The RNA of ZNF667-AS1 was mainly located on the nucleus. b. The mRNA of ZNF667 was mainly located on the nucleus. c. Overexpression of ZNF667-AS1 increased the expression of ZNF667 in mRNA level, detected by qRT-PCR. d. Overexpression of ZNF667 didn’t increase the expression of ZNF667-AS1 in mRNA level, detected by qRT-PCR. e. Overexpression of ZNF667-AS1 increased the expression of ZNF667 in protein level, detected by western blot. f and g. Overexpression of ZNF667-AS1 increased the expression of EMT associated markers. h and i. Overexpression of ZNF667 increased the expression of EMT associated markers partially. In Fig. 7c-i, pcDNA3.1: the vector control group; ZNF667-AS1: ZNF667-AS1 over-expression group; ZNF667: ZNF667 over-expression group. The difference was statistically significant, **P < 0.01

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Journal of Biomedical Science

ISSN: 1423-0127