Table 1 Expression levels of let-7d and miR-205 depending on the clinicopathological parameters in HNSCC patients; T-test, p < 0.05 was considered significant
From: Low let-7d and high miR-205 expression levels positively influence HNSCC patient outcome
Parameter | Group | Cases analyzed | let-7d | miR-205 | ||
|---|---|---|---|---|---|---|
Mean ± SEM | p-val | Mean ± SEM | p-val | |||
Age | < 61.3 | 159 | 7.621 ± 0.04545 | 0.3846 | 13.49 ± 0.08659 | 0.8371 |
> 61.3 | 147 | 7.564 ± 0.04723 | 13.51 ± 0.08951 | |||
Gender | Female | 95 | 7.537 ± 0.06120 | 0.2445 | 13.59 ± 0.09850 | 0.621 |
Male | 221 | 7.619 ± 0.03845 | 13.46 ± 0.07811 | |||
Alcohol | Yes | 206 | 7.650 ± 0.03906 | 0.0227 | 13.5 ± 0.07550 | 0.5678 |
No | 97 | 7.491 ± 0.05784 | 13.5 ± 0.1092 | |||
Grade | G1 + G2 | 219 | 7.515 ± 0.03841 | 0.0002 | 13.48 ± 0.06774 | 0.5185 |
G3 + G4 | 80 | 7.796 ± 0.06118 | 13.57 ± 0.1461 | |||
Cancer Stage | I + II | 74 | 7.554 ± 0.06325 | 0.6672 | 13.52 ± 0.1002 | 0.3658 |
III + IV | 197 | 7.587 ± 0.04059 | 13.39 ± 0.08370 | |||
T Stage | T1 + T2 | 118 | 7.555 ± 0.05406 | 0.4987 | 13.42 ± 0.08618 | 0.5219 |
T3 + T4 | 154 | 7.602 ± 0.04398 | 13.44 ± 0.09825 | |||
N Stage | N0 | 154 | 7.531 ± 0.04499 | 0.0729 | 13.55 ± 0.07323 | 0.3485 |
N1 + N2 + N3 | 140 | 7.651 ± 0.04992 | 13.41 ± 0.1054 | |||
Perineural Invasion | Yes | 105 | 7.555 ± 0.05409 | 0.5565 | 13.27 ± 0.1050 | 0.0165 |
No | 110 | 7.601 ± 0.05588 | 13.62 ± 0.1045 | |||
Angiolymphatic Invasion | Yes | 67 | 7.762 ± 0.05671 | 0.0024 | 13.15 ± 0.1663 | 0.008 |
No | 139 | 7.506 ± 0.05074 | 13.59 ± 0.07981 | |||
Disease Surgical Margin Status | Negative | 210 | 7.550 ± 0.03765 | 0.5931 | 13.45 ± 0.07263 | 0.1907 |
Positive | 30 | 7.607 ± 0.09610 | 13.23 ± 0.1742 | |||
Lymph Node Neck Dissection Indicator | Yes | 246 | 7.575 ± 0.03530 | 0.1731 | 13.43 ± 0.07065 | 0.0091 |
No | 59 | 7.688 ± 0.08177 | 13.79 ± 0.1249 | |||
HPV p16 status | Negative | 16 | 7.730 ± 0.1301 | 0.26 | 13.63 ± 0.4052 | 0.1429 |
Positive | 48 | 7.552 ± 0.07919 | 13.32 ± 0.1816 | |||