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Fig. 7 | Journal of Biomedical Science

Fig. 7

From: Effects of oxytocin on prosocial behavior and the associated profiles of oxytocinergic and corticotropin-releasing hormone receptors in a rodent model of posttraumatic stress disorder

Fig. 7

The CRHR2 mRNA levels and protein expressions in the mPFC, hippocampus, and amygdala. OXT could decrease SPS-increased mPFC CRHR2 mRNA level, and this effect could be blocked by ASB (a). OXT and ASB reduced the hippocampus CRHR2 mRNA level in SPS rats (b). SPS and drugs (OXT and ASB) did not affect the CRHR2 mRNA level in amygdala (C). SPS and drugs (OXT and ASB) did not affec the CRHR2 protein expressions in the mPFC, hippocampus, and amygdala, excepting ASB reduced hippocampus CRHR2 expression (D-F). SPS = single prolonged stress, VEH = vehicle, OXT = oxytocin, ASB = atosiban, OXTR = oxytocin receptor. Bars represent mean ± SEM; *p < 0.05, **p < 0.01, ***p < 0.01, compared with Control-Veh; ##p < 0.01, ###p < 0.001, compared with Control-OXT. N = 5 for the mRNA levels (A-C); N = 4 for the protein expressions (d-f)

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