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Table 1 Summary of the genes/signals regulated by genomic or nongenomic action of TH/THR signal axis

From: Molecular functions and clinical impact of thyroid hormone-triggered autophagy in liver-related diseases

Molecular function Gene/signal name Reference
Nongenomic regulation by TH/THR
 Membrane receptor of TH Integrin αvβ3 [55, 56]
 Signal transductor Src kinase [59]
PI3K/Akt [7, 59, 68]
p-ERK1/2 [58, 61,62,63,64,65,66, 60, 67]
mTOR/p70S6K [69]
eNOS [7, 68]
 Transcriptional factor Estrogen receptor [62, 67]
STAT3 [64]
HIF1-α [58, 60, 70, 69, 71]
β-catenin [77]
 Metabolic regulator GLUT1 [71]
PFKP [71]
MCT 4 [71]
 Na-K-ATPase KCNH2 [72]
 Apoptosis regulator FOXO1 [136, 137, 176]
BCL2L11 [176]
Genomic regulation by TH/THR
 Transcriptional coregulator of THR SP1 [48]
p53 [49]
Oct-1 [50]
GHF-1 [51, 52]
CTCF [53, 54]
LCOR [47]
 Autophagy regulator DAPK2 [16]
Betatrophin [26]
 Cell cycle regulator UHRF1 [171]
STMN1 [172]
Mir-214 [173]
BC200 [174]
 Apoptosis regulator TRAIL [175]
 Metastatic regulator BSSP4 [178]
LCN2 [180]
mir-130b [177]
mir-21 [179]