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Fig. 2 | Journal of Biomedical Science

Fig. 2

From: Molecular mechanisms of cisplatin-induced nephrotoxicity: a balance on the knife edge between renoprotection and tumor toxicity

Fig. 2

Cell subtypes that play crucial role in the pathogenesis of cisplatin-induced AKI. Cisplatin-induced AKI involves the coordinated actions of proximal tubular epithelial, endothelial, innate and adaptive immune cells. Abbreviations: ROS: Reactive oxygen species; IL: Interleukin; TNF-α: Tumor necrosis factor alpha; MIF: Macrophage migration inhibitory factor; Mincle: Macrophage-inducible C-type lectin; CXCL1: Chemokine (C-X-C motif) ligand 1; Kim-1: Kidney injury molecule-1; ICAM-1: Intercellular adhesion molecule-1

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Journal of Biomedical Science

ISSN: 1423-0127