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Fig. 5 | Journal of Biomedical Science

Fig. 5

From: Promyelocytic leukemia zinc finger is involved in the formation of deep layer cortical neurons

Fig. 5

Differentially expressed genes in the embryonic brain of Plzflu/lu mice with functions related to neurogenesis. a, E10.5 forebrain and midbrain were collected for gene expression profiling by microarray. The 64 candidate genes with > or < 1.3-fold changes in expression by Plzflu/lu mice were further analyzed by ToppFun (https://toppgene.cchmc.org/). Using the default parameters to annotate target genes for GO Biological Process, the top five physiological system development and function categories were identified. Significance referred to the –log (p-value). The numbers in blue bars represent the numbers of genes involved in the category. b, Potential genes involved in formation of neural precursor cells. Arx: Aristaless related homeobox; Ascl1 (Mash1): Achaete-scute family bHLH transcription factor 1; Shh: Sonic hedgehog. The numbers under the circles represent the fold changed between Plzflu/lu to Plzfwt/wt

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