Fig. 3
From: RETRACTED ARTICLE: Molecular mechanisms in progression of HPV-associated cervical carcinogenesis
Schematic presentation of DNA methylation by E6 and E7 oncoproteins: Binding of E6-E6AP complex to p53 to leads to ubiquitination and degradation of p53 and induces overexpression and activity of DNA methyltransferase (DNMT) 1. Binding of E7 to pRb causes the release of E2F, favoring the overexpression of DNMT1. The activities of E6 and E7 causing increase in activity of DNMT1 results in hypermethylation of tumor-suppressor gene promoters, leading to silencing of genes, cellular transformation and tumorigenesis