Fig. 6
From: RETRACTED ARTICLE: Molecular mechanisms in progression of HPV-associated cervical carcinogenesis
Schematic structure of oncoprotein E7. Protein structure and functions of HPV16 E7 and the most important amino acid motifs required for integrity and protein functions. Relative locations of the regions with sequence motifs similar to a portion of conserved region 1 (CR1) and the entire CR2 of adenovirus E1A are shown with the pRB-binding site LXCXE in the CR2. Zinc binding motifs are indicated in grey boxes. The zinc finger is shown together with the regions involved in pRb binding (LXCXE) and the two serine residues (31 and 32) that are susceptible to casein kinase II (CKII) phosphorylation. Functions associated with proteins in different regions are indicated by PI3K