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Fig. 4 | Journal of Biomedical Science

Fig. 4

From: HDAC6 dysfunction contributes to impaired maturation of adult neurogenesis in vivo: vital role on functional recovery after ischemic stroke

Fig. 4

Lasting deleterious influence on dendritic maturation after hypoxic challenge. (a) Representative images of the retroviral labeled newly generated neurons born at different time points (7, 14, 21 or 28 days) after MCAO surgery and imaged for their dendritic elaboration at 14dpi. The scale bar is 25 μm. (b) Quantification of total dendritic length of individual 14 dpi newborn neurons born at 7, 14, 21 or 28 days after MCAO surgery. (c) Quantification of the number of dendritic branches from individual 14 dpi newborn neurons born at 7, 14, 21 or 28 days after MCAO surgery. Data are presented as mean ± SEM. n = 20 to 40 cells from four mice, two-tailed unpaired t-test. * p < 0.05 compared to sham-operated control. “ns” represents no significant

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