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Table 1 circRNAs that function as miRNA sponges

From: The emerging roles and functions of circular RNAs and their generation

CircRNA Biological functions miRNA Targets Cell type Ref
CDR1as Neural development
Insulin secretion
Myocardial infarction
Promotes proliferation
Anti-oncogenic
Promotes proliferation
Promotes proliferation/metastasis
Osteoblastic differentiation
miR-7/− 671
miR-7
miR-7
miR-876-5p
miR-7/−135a
miR-7
miR-7
miR-7
Fos
Pax6, Myrip
PARP, SP1
MAGE-A
P21
CCNE1, PIK3CD, EGFR
HOXB13
GDF5
Neural tissue
Islet cells
Cardiomyocytes
ESCC
Bladder cancer
NSCLC
ESCC
PDLSC
[15, 42, 44, 70, 71, 73, 87,88,89,90]
SRY Sex-determining miR-138   Testis [16]
circBIRC6 Pluripotency maintenance miR-34a/−145 NANOG, OCT4, SOX2 hESCs, iPSCs [36]
circHIPK3 Promotes proliferation miR-124/− 152/−193a/−29a/−29b/− 338/− 379/− 584/− 654 IL6R, DLX2 Cancer tissues [41, 46, 48, 74, 91, 92, 114]
Inhibits cancer progression
β-cell function
Promotes proliferation
Promotes proliferation/migration
Promotes proliferation/migration
Promotes proliferation
miR-558
miR-124-3p/338-3p
miR-30a-3p
miR-124
miR-7
miR-124
HPSE
Slc2a2, Akt1, Mtpn
FZD4, WNT2, VEGF-C
AQP3
FAK, IGF1R, EGFR
ROCK1, CDK6
Bladder cancer
β-cells
Retinal endothelial cells
HCC
CRC
Gallbladder cancer
circWDR77 Promotes proliferation miR-124 FGF2 VSMC [43]
circNT5E Promotes cancer progression miR-422a PIK3CA, NT5E Glioblastoma [45]
circZFR Promotes cancer progression
Promotes cancer progression
Promotes cancer progression
Inhibits cancer progression
miR-3619-5p
miR-4302
miR-1261
miR-130a/−107
CTNNB1
ZNF121
C8orf4
PTEN
HCC
Lung cancer
PTC
Gastric Cancer
[47, 52, 94, 95]
circTCF25 Promotes cancer progression miR-103a-3p/− 107 CDK6 Bladder carcinoma [49]
Hsa_circ_0008039 (circPRKAR1B) Promote proliferation/migration miR-432-5p E2F3 Breast cancer cells [51]
circITCH Inhibits proliferation
Inhibits cancer progression
Inhibits cancer progression
Inhibits cancer progression
miR-214
miR-17/− 224
miR-22-3p
miR-145
ITCH/CTNNB1
P21, PTEN
CBL/CTNNB1
RASA1
CRC
Bladder cancer
Papillary thyroid cancer
Ovarian cancer
[53,54,55, 93]
Hsa_circ_0002052
(circPAPPA)
Inhibits cancer progression miR-1205 APC2 Osteosarcoma [56]
circMYLK Promotes cancer progression miR-29a LAMC, TRAF4 PC-a [58]
circRNA_0084043
(circADAM9)
Promotes cancer progression miR-153-3p SNAIL melanoma [59]
circIRAK3 Promote migration/invasion miR-3607 FOXC1 Breast cancer cells [60]
circNASP Promotes cancer progression miR-1253 FOXF1 Osteosarcoma [61]
circMAN2B2 Promotes proliferation/migration miR-1275 FOXK1 Lung cancer [62]
circSHKBP1 Promotes angiogenesis miR-544a/− 379 FOXP1, FOXP2 Endothelial cells [63]
circSMAD2 Inhibits EMT miR-629 TRIM33 HCC [64]
circFOXO3 Inhibits cancer progression miR-155 FOXO3 NSCLC [65]
circFGFR4 Myoblast differentiation miR-107 WNT3A Bovine myoblast [67]
circSVIL Myoblast differentiation miR-203 MEF2C, JUN Chicken myoblast [68]
circZC3H4 Macrophage activation miR-212 ZC3H4 Alveolar macrophage [75]
circHIPK2 Astrocyte activation
ER stress
miR-124
miR-506-3p
SIGMAR1
SIGMAR1
Astrocyte
HPF-a
[77, 115]
circHECTD1 Inhibits astrocyte activation miR-142 TIPARP Brain [78]
circGRB10 Inhibits apoptosis miR-328-5p ERBB2 NP cells [79]
Hsa_circ_0043256 (circACACA) Induced apoptosis miR-1252 ITCH NSCLC [80]
circDLGAP4 Ameliorates ischemic stroke miR-143 HECTD1 Brain tissue [82]
circVMA21 Against IDD miR-200c XIAP NP cells [83]
circZNF609 Retinal neurodegeneration
Vascular dysfunction
Myoblast differentiation
miR-615
miR-615
miR-194-5p
METRN
MEF2A
BCLAF1
RGC
Vascular endothelial
C2C12
[84, 85, 116]
circPVT1 Promotes proliferation miR-497-5p Aurka, Bub1, mKi67 HNSCC [117]
circMTO1 Inhibits cancer progression miR-9 P21 HCC [118]
circITGA7 Inhibits proliferation/metastasis miR-370-3p NF1 CRC [119]
circACTA2 VSMC contraction miR-548f-5p SMA HASMC [120]
circCCDC66 Promotes cancer progression miR-33b/− 93/− 185 DNMT3B, MYC, EZH2, CRC [121]
circFBLIM1 Promotes cancer progression miR-346 FBLIM1 HCC [122]
circATP2B1 Promotes invasion miR-204-3p FN1 CCRCC [123]
circLARP4 Inhibits proliferation/invasion miR-424-5p LATS1 Gastric cancer [124]
Hsa_circ_0000799 (circBPTF) Promotes cancer progression miR-31-5p RAB27A Bladder cancer [125]
circRNA_000203 (circMYO9A) Promotes fibrosis miR-26b-5p Col1a2, Col3a1, SMA, CTGF Cardiac fibroblast [126]
circRNA_8924 (circC1orf116) Promotes cancer progression miR-518d-5p/− 519-5p CBX8 Cervical cancer cells [127]
circRNA_008913 (circADAT1) Reduces carcinogenesis miR-889 DAB2IP HaCaT [128]
  1. Abbreviations: CCRCC (Clear Cell Renal Cell Carcinoma), CRC (Colorectal cancer), ESCC (Esophageal squamous cell carcinoma), HASMC (Human aortic smooth muscle cells), HCC (Hepatocellular carcinoma), HNSCC (Head and neck squamous cell carcinoma), IDD (intervertebral disc degeneration), NP cells (Nucleus pulposus cells), NSCLC (Non-small-cell lung carcinoma), PDLSC (Periodontal ligament stem cells), PTC (Papillary thyroid cancer), RGC (Retinal ganglion cells), VSMC (Vascular smooth muscle cells)