The emerging roles and functions of circular RNAs and their generation

Yu, Chun-Ying; Kuo, Hung-Chih

doi:10.1186/s12929-019-0523-z

Journal of Biomedical Science

Table 1 circRNAs that function as miRNA sponges

From: The emerging roles and functions of circular RNAs and their generation

CircRNA	Biological functions	miRNA	Targets	Cell type	Ref
CDR1as	Neural development Insulin secretion Myocardial infarction Promotes proliferation Anti-oncogenic Promotes proliferation Promotes proliferation/metastasis Osteoblastic differentiation	miR-7/− 671 miR-7 miR-7 miR-876-5p miR-7/−135a miR-7 miR-7 miR-7	Fos Pax6, Myrip PARP, SP1 MAGE-A P21 CCNE1, PIK3CD, EGFR HOXB13 GDF5	Neural tissue Islet cells Cardiomyocytes ESCC Bladder cancer NSCLC ESCC PDLSC	[15, 42, 44, 70, 71, 73, 87,88,89,90]
SRY	Sex-determining	miR-138		Testis	[16]
circBIRC6	Pluripotency maintenance	miR-34a/−145	NANOG, OCT4, SOX2	hESCs, iPSCs	[36]
circHIPK3	Promotes proliferation	miR-124/− 152/−193a/−29a/−29b/− 338/− 379/− 584/− 654	IL6R, DLX2	Cancer tissues	[41, 46, 48, 74, 91, 92, 114]
circHIPK3	Inhibits cancer progression β-cell function Promotes proliferation Promotes proliferation/migration Promotes proliferation/migration Promotes proliferation	miR-558 miR-124-3p/338-3p miR-30a-3p miR-124 miR-7 miR-124	HPSE Slc2a2, Akt1, Mtpn FZD4, WNT2, VEGF-C AQP3 FAK, IGF1R, EGFR ROCK1, CDK6	Bladder cancer β-cells Retinal endothelial cells HCC CRC Gallbladder cancer	[41, 46, 48, 74, 91, 92, 114]
circWDR77	Promotes proliferation	miR-124	FGF2	VSMC	[43]
circNT5E	Promotes cancer progression	miR-422a	PIK3CA, NT5E	Glioblastoma	[45]
circZFR	Promotes cancer progression Promotes cancer progression Promotes cancer progression Inhibits cancer progression	miR-3619-5p miR-4302 miR-1261 miR-130a/−107	CTNNB1 ZNF121 C8orf4 PTEN	HCC Lung cancer PTC Gastric Cancer	[47, 52, 94, 95]
circTCF25	Promotes cancer progression	miR-103a-3p/− 107	CDK6	Bladder carcinoma	[49]
Hsa_circ_0008039 (circPRKAR1B)	Promote proliferation/migration	miR-432-5p	E2F3	Breast cancer cells	[51]
circITCH	Inhibits proliferation Inhibits cancer progression Inhibits cancer progression Inhibits cancer progression	miR-214 miR-17/− 224 miR-22-3p miR-145	ITCH/CTNNB1 P21, PTEN CBL/CTNNB1 RASA1	CRC Bladder cancer Papillary thyroid cancer Ovarian cancer	[53,54,55, 93]
Hsa_circ_0002052 (circPAPPA)	Inhibits cancer progression	miR-1205	APC2	Osteosarcoma	[56]
circMYLK	Promotes cancer progression	miR-29a	LAMC, TRAF4	PC-a	[58]
circRNA_0084043 (circADAM9)	Promotes cancer progression	miR-153-3p	SNAIL	melanoma	[59]
circIRAK3	Promote migration/invasion	miR-3607	FOXC1	Breast cancer cells	[60]
circNASP	Promotes cancer progression	miR-1253	FOXF1	Osteosarcoma	[61]
circMAN2B2	Promotes proliferation/migration	miR-1275	FOXK1	Lung cancer	[62]
circSHKBP1	Promotes angiogenesis	miR-544a/− 379	FOXP1, FOXP2	Endothelial cells	[63]
circSMAD2	Inhibits EMT	miR-629	TRIM33	HCC	[64]
circFOXO3	Inhibits cancer progression	miR-155	FOXO3	NSCLC	[65]
circFGFR4	Myoblast differentiation	miR-107	WNT3A	Bovine myoblast	[67]
circSVIL	Myoblast differentiation	miR-203	MEF2C, JUN	Chicken myoblast	[68]
circZC3H4	Macrophage activation	miR-212	ZC3H4	Alveolar macrophage	[75]
circHIPK2	Astrocyte activation ER stress	miR-124 miR-506-3p	SIGMAR1 SIGMAR1	Astrocyte HPF-a	[77, 115]
circHECTD1	Inhibits astrocyte activation	miR-142	TIPARP	Brain	[78]
circGRB10	Inhibits apoptosis	miR-328-5p	ERBB2	NP cells	[79]
Hsa_circ_0043256 (circACACA)	Induced apoptosis	miR-1252	ITCH	NSCLC	[80]
circDLGAP4	Ameliorates ischemic stroke	miR-143	HECTD1	Brain tissue	[82]
circVMA21	Against IDD	miR-200c	XIAP	NP cells	[83]
circZNF609	Retinal neurodegeneration Vascular dysfunction Myoblast differentiation	miR-615 miR-615 miR-194-5p	METRN MEF2A BCLAF1	RGC Vascular endothelial C2C12	[84, 85, 116]
circPVT1	Promotes proliferation	miR-497-5p	Aurka, Bub1, mKi67	HNSCC	[117]
circMTO1	Inhibits cancer progression	miR-9	P21	HCC	[118]
circITGA7	Inhibits proliferation/metastasis	miR-370-3p	NF1	CRC	[119]
circACTA2	VSMC contraction	miR-548f-5p	SMA	HASMC	[120]
circCCDC66	Promotes cancer progression	miR-33b/− 93/− 185	DNMT3B, MYC, EZH2,	CRC	[121]
circFBLIM1	Promotes cancer progression	miR-346	FBLIM1	HCC	[122]
circATP2B1	Promotes invasion	miR-204-3p	FN1	CCRCC	[123]
circLARP4	Inhibits proliferation/invasion	miR-424-5p	LATS1	Gastric cancer	[124]
Hsa_circ_0000799 (circBPTF)	Promotes cancer progression	miR-31-5p	RAB27A	Bladder cancer	[125]
circRNA_000203 (circMYO9A)	Promotes fibrosis	miR-26b-5p	Col1a2, Col3a1, SMA, CTGF	Cardiac fibroblast	[126]
circRNA_8924 (circC1orf116)	Promotes cancer progression	miR-518d-5p/− 519-5p	CBX8	Cervical cancer cells	[127]
circRNA_008913 (circADAT1)	Reduces carcinogenesis	miR-889	DAB2IP	HaCaT	[128]

Abbreviations: CCRCC (Clear Cell Renal Cell Carcinoma), CRC (Colorectal cancer), ESCC (Esophageal squamous cell carcinoma), HASMC (Human aortic smooth muscle cells), HCC (Hepatocellular carcinoma), HNSCC (Head and neck squamous cell carcinoma), IDD (intervertebral disc degeneration), NP cells (Nucleus pulposus cells), NSCLC (Non-small-cell lung carcinoma), PDLSC (Periodontal ligament stem cells), PTC (Papillary thyroid cancer), RGC (Retinal ganglion cells), VSMC (Vascular smooth muscle cells)

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ISSN: 1423-0127

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