The emerging roles and functions of circular RNAs and their generation

Table 2 CircRNAs that function as protein decoys

CircRNA	Biological functions	Interacting protein	Cell type	Ref
circFOXO3	Inhibits cell cycle progression Cardiac senescence Induces apoptosis	P21, CDK2 ID-1, E2F1, FAK, HIF1α MDM2, P53	Non-cancer cells Heart tissue Non-cancer cells	[96, 97, 129]
circANRIL	rRNA maturation	PES1	Vascular tissue	[81]
circHECTD1	Macrophage activation	ZC3H12A	Macrophage	[76]
circDNMT1	Promotes proliferation	P53, AUF1	Breast cancer cells	[98]
circSMARCA5	Tumor suppressor	SRSF1	Glioblastoma	[99]
circMTO1	Inhibits proliferation	TRAF4	Breast cancer cells	[100]
circAMOTL1	Promotes cell survival	PDK1, AKT1	Cardiomyocytes	[101]
circPABPN1	Suppresses PABPN1 translation	HuR	HeLa	[24]

ISSN: 1423-0127