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Table 1 Changes of NAD levels in metabolic tissues with obesity or aging

From: Implications of altered NAD metabolism in metabolic disorders

Model Tissue Change Description Confirmatiom References
Obesity Liver C57BL/6 congenic mice fed a HFD for 6–8 months HPLC [8]
BALB/c mice fed a HFD for 16–20 weeks Enzymatic [96]
C57BL/6 J mice fed a HFD for 12 weeks LC/MS [9]
C57BL/6 J mice fed a HFHSD for 9 or 18 weeks LC/MS [10]
C57BL/6JBomTac mice fed a HFD for 6–48 weeks LC/MS [11]
Skeletal muscle C57BL/6 mice fed a HFD for 6–8 months HPLC [8]
C57BL/6 mice fed a HFD from 3 to 9 months HPLC [12]
C57BL/6 mice fed a HFD from 6 to 16 weeks LC/MS [13]
Adipose tissue C57BL/6 mice fed a HFD for 6–8 months HPLC [8]
C57BL/6 congenic mice fed a HFD from 6 to 16 weeks Enzymatic [14]
Hypothalamus C57BL/6 mice fed a HFHSD for 4 weeks LC/MS [15]
db/db mice at 8 months of age LC/MS [15]
Aging Liver C57BL/6 mice (25–31 months old v.s. 3–6 months old) HPLC [8]
C57BL/6 J mice (24 months old v.s. 6 months old) HPLC [16]
Human (> 60 years old v.s. < 45 years old) Enzymatic [17]
Male C57BL/6 J mice (20 months old v.s. 4 months old) Enzymatic [17]
Male C57BL/6 mice (32 months old v.s. 5 months old) LC/MS [18]
Male C57BL/6 N mice (24 months old v.s. 3 months old) LC/MS [19]
Skeletal muscle C57BL/6 mice (25–31 months old v.s. 3–6 months old) HPLC [8]
C57BL/6 J mice (22 months old v.s. 6 months old) Enzymatic [20]
C57BL/6 J mice (24 months old v.s. 6 months old) HPLC [16]
Male C57BL/6 mice (32 months old v.s. 5 months old) Enzymatic [18]
C57BL/6 mice (24 months old v.s. 4 months old) HPLC [21]
C57BL/6 J mice (22–24 months old v.s. 1 months old) Enzymatic [22]
Male C57BL/6 N mice (24 months old v.s. 3 months old) LC/MS [19]
Adipose tissue C57BL/6 mice (25–31 months old v.s. 3–6 months old) HPLC [8]
Male C57BL/6 mice (32 months old v.s. 5 months old) Enzymatic [18]
  1. HPLC High Performance Liquid Chromatography, LC/MS Liquid Chromatography-Mass spectrometry