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Table 1 Changes of NAD levels in metabolic tissues with obesity or aging

From: Implications of altered NAD metabolism in metabolic disorders

Model

Tissue

Change

Description

Confirmatiom

References

Obesity

Liver

↓

C57BL/6 congenic mice fed a HFD for 6–8 months

HPLC

[8]

↓

BALB/c mice fed a HFD for 16–20 weeks

Enzymatic

[96]

↓

C57BL/6 J mice fed a HFD for 12 weeks

LC/MS

[9]

↓

C57BL/6 J mice fed a HFHSD for 9 or 18 weeks

LC/MS

[10]

→

C57BL/6JBomTac mice fed a HFD for 6–48 weeks

LC/MS

[11]

Skeletal muscle

↓

C57BL/6 mice fed a HFD for 6–8 months

HPLC

[8]

↓

C57BL/6 mice fed a HFD from 3 to 9 months

HPLC

[12]

↓

C57BL/6 mice fed a HFD from 6 to 16 weeks

LC/MS

[13]

Adipose tissue

↓

C57BL/6 mice fed a HFD for 6–8 months

HPLC

[8]

↓

C57BL/6 congenic mice fed a HFD from 6 to 16 weeks

Enzymatic

[14]

Hypothalamus

↓

C57BL/6 mice fed a HFHSD for 4 weeks

LC/MS

[15]

↓

db/db mice at 8 months of age

LC/MS

[15]

Aging

Liver

→

C57BL/6 mice (25–31 months old v.s. 3–6 months old)

HPLC

[8]

↓

C57BL/6 J mice (24 months old v.s. 6 months old)

HPLC

[16]

↓

Human (> 60 years old v.s. < 45 years old)

Enzymatic

[17]

↓

Male C57BL/6 J mice (20 months old v.s. 4 months old)

Enzymatic

[17]

↓

Male C57BL/6 mice (32 months old v.s. 5 months old)

LC/MS

[18]

↓

Male C57BL/6 N mice (24 months old v.s. 3 months old)

LC/MS

[19]

Skeletal muscle

↓

C57BL/6 mice (25–31 months old v.s. 3–6 months old)

HPLC

[8]

↓

C57BL/6 J mice (22 months old v.s. 6 months old)

Enzymatic

[20]

↓

C57BL/6 J mice (24 months old v.s. 6 months old)

HPLC

[16]

↓

Male C57BL/6 mice (32 months old v.s. 5 months old)

Enzymatic

[18]

↓

C57BL/6 mice (24 months old v.s. 4 months old)

HPLC

[21]

↓

C57BL/6 J mice (22–24 months old v.s. 1 months old)

Enzymatic

[22]

↓

Male C57BL/6 N mice (24 months old v.s. 3 months old)

LC/MS

[19]

Adipose tissue

↓

C57BL/6 mice (25–31 months old v.s. 3–6 months old)

HPLC

[8]

↓

Male C57BL/6 mice (32 months old v.s. 5 months old)

Enzymatic

[18]

  1. HPLC High Performance Liquid Chromatography, LC/MS Liquid Chromatography-Mass spectrometry