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Fig. 5 | Journal of Biomedical Science

Fig. 5

From: Reactive oxygen species-dependent mitochondrial dynamics and autophagy confer protective effects in retinal pigment epithelial cells against sodium iodate-induced cell death

Fig. 5

Roles of p38, JNK and Akt in mitochondrial dynamics and cell viability in NaIO3-treated RPE cells. a Cells were treated with specific kinase inhibitors (U0126, AktI, SB203580, SP600125) and NaIO3 for 24 h. Cell viability was determined. # p < 0.05, indicating significant effects of kinase inhibitors on NaIO3-induced cell death. b After drug treatment for 6 h, Tom20 was used to stain mitochondria and confocal microscopy was taken to determine the mitochondrial dynamics. Scale bars indicated 10 μm. c After drug treatment as indicated, Drp-1 phosphorylation at S616 was determined by immunoblotting. Data were representative of 3 independent experiments

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