Skip to main content
Figure 2 | Journal of Biomedical Science

Figure 2

From: Basics and applications of tumor-derived extracellular vesicles

Figure 2

Potential applications of tumor-derived EVs. Investigations of the specific expression patterns of mRNAs/miRNAs and transcriptomic, proteomic, and phosphoproteomic biomarkers in tumor-derived EVs, have indicated a powerful role for tumor-derived EVs in cancer diagnosis. The functional effects of tumor-derived EVs on the regulation of drug sensitivity or resistance in cancer suggest the role of tumor-derived EVs in cancer therapy. Regarding the role of EVs in immunotherapy, exosomes have been shown to modulate NK effector functional effects, reinforce the immunosuppressive function of MDSCs, and facilitate anticancer immune responses. A growing number of studies have indicated that the RGD peptide, cyclic RGDyK peptide, and CD47-modified exosomes promote the cell targeting, binding affinity, efficacy, and specificity of exosomes, suggesting the potential applications of EVs in targeted delivery. Moreover, the EV-based therapeutic drug delivery system exhibits increased biocompatibility, low toxicity, and stability

Back to article page