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Table 1 Associations between CPAP expression, clinical parameters and disease-free survival/ overall survival

From: Hepatitis B virus X protein (HBx) enhances centrosomal P4.1-associated protein (CPAP) expression to promote hepatocarcinogenesis

Clinical parameters N Disease-free survival (years) Overall survival (years)
Mean 95% CI p-value Mean 95% CI p-value
CPAP expression
 < 1.5X 47 2.776 2.345 3.237 0.039* 3.858 3.376 4.340 0.521
1.5X 85 2.644 1.815 3.472   7.886 7.122 8.650  
Gender
 Male 102 2.379 2.039 2.720 0.922 7.616 6.837 8.394 0.413
 Female 30 2.825 1.768 3.881   7.983 6.941 9.025  
Age (yrs)
 < 50 30 2.508 1.994 3.021 0.196 4.001 3.507 4.495 0.867
50 102 2.869 1.968 3.770   7.736 6.987 8.486  
Liver cirrhosis
 No 89 2.042 1.709 2.376 0.231 7.855 7.040 8.671 0.771
 Yes 43 3.387 2.197 4.577   7.400 6.364 8.437  
AST/GOT (U/L)
 < 52 80 3.827 3.124 4.530 0.118 8.386 7.749 9.023 0.010*
52 52 2.189 1.658 2.720   6.532 5.278 7.787  
ALT/GPT (U/L)
 < 111 120 3.083 2.156 4.010 0.074 8.030 7.423 8.637 0.045*
111 12 1.706 0.822 2.591   2.648 1.935 3.361  
AFP (ng/ml)
 < 400 103 2.954 2.048 3.860 0.929 7.825 7.091 8.559 0.510
400 29 2.397 1.776 3.018   7.264 5.925 8.604  
Differentiation
 Well 25 2.583 1.891 3.274 0.063 7.957 7.254 8.661 0.009*
 Moderate 91 3.850 3.176 4.525   7.754 6.950 8.559  
 Poor 16 1.207 0.764 3.900   3.399 2.227 4.571  
Tumor size (cm)
 < 5 87 3.536 2.455 4.617 0.000* 8.346 7.822 8.870 0.000*
5 45 1.529 1.086 1.973   6.007 4.500 7.513  
Tumor number
 Single 107 3.034 2.092 3.976 0.921 7.764 7.033 8.495 0.631
 > 1 25 2.155 1.572 2.739   3.227 2.735 3.718  
Vascular invasion
 Absence 94 3.014 2.077 3.951 0.601 8.168 7.468 8.869 0.057
 Presence 38 2.110 1.626 2.593   6.764 5.532 7.997  
AJCC Stage
 I&II 108 3.451 2.402 4.501 0.000* 8.238 7.626 8.850 0.001*
 III 24 0.910 0.526 1.295   3.074 2.281 3.867  
  1. *, statistically significant