From: Sudden Cardiac Death (SCD) – risk stratification and prediction with molecular biomarkers
Process | Biomarkers | Association with CVD | Strength of evidencea | Ref |
---|---|---|---|---|
Oxidative stress | Reduced (cysteine and glutathione) and oxidized (cystine and glutathione disulphide) aminothiols | High cystine (oxidized) and low glutathione (reduced) levels were associated with higher mortality in patients with CAD | ++ | [45] |
Heat shock protein 70 (HSP70) | High levels of HSP70 were associated with low CAD risk | + | [47] | |
High HSP70 levels were associated with increased risk of cardiac death | [48] | |||
Inflammation | Interleukin (IL) such as IL-6 and IL-18 | Higher IL-6 levels were associated with SCD and was an independent predictor of sudden death | +++ | [51] |
High levels of IL-6 were associated with increased burden of atherosclerosis and higher risk of major adverse cardiac events (MACE) risk | [52] | |||
Higher IL-6 levels were associated with atherosclerotic cardiovascular disease (ASCVD) events, heart failure (HF) and mortality | [53] | |||
[55] | ||||
Higher levels of IL-18 and IL-12 were associated with increased risk of cardiovascular events | ||||
C-reactive protein (CRP) | High CRP levels were associated with greater mortality and risk of cardiovascular disease | ++ | [60] | |
CRP levels were not significantly associated with sudden death and SCD risk | ||||
Lipoprotein-associated phospholipase A2 (Lp-PLA2) | Higher Lp-PLA2 levels were associated with increased risk of coronary heart disease and was an independent predictor of CHD events | + | ||
Myeloperoxidase (MPO) | MPO levels were associated with the incidence and severity of CAD | + | [66] | |
Urokinase-type plasminogen activator receptor (uPAR) | High suPAR levels were associated with increased risk of CVD | ++ | ||
Matrix metalloproteinases (MMP) | Higher levels of MMP-1, − 2, − 8 and − 9 were associated with acute coronary syndromes and CAD | + | ||
Pentraxin-3 (PTX3) | PTX3 was associated with higher risk of mortality in patients with chronic heart failure | + | [72] | |
Neurohormonal regulation | Renin and aldosterone | Higher plasma renin and aldosterone levels were associated with increased risk of cardiovascular mortality and adverse outcome in ST-elevation myocardial infarction (STEMI) | +++ | |
Adrenomedullin (ADM) | High ADM levels were associated with heart failure | ++ | ||
Mid-regional pro–atrial natriuretic peptide (MR-proANP) demonstrated diagnostic and prognostic utility in patients with acute heart failure (AHF) | ||||
Copeptin | High copeptin levels were associated with increased mortality, readmissions, and emergency department visits in patients with acute heart failure as well as excess mortality in patients with chronic HF | + | ||
Hemodynamic properties | Natriuretic peptides (NP), i.e. (B-type natriuretic peptide) BNP or (N-terminal pro B-type natriuretic peptide) NT-proBNP | Higher NT-proBNP levels were associated with increased risk of SCD | +++ | |
High BNP levels were an independent predictor of sudden death in patient with chronic heart failure | [90] | |||
High BNP levels were associated with higher risk of death/mortality in patients with acute myocardial infarction | [91] | |||
Myocardial stress, necrosis, fibrosis and tissue regeneration | Cardiac troponins (cTn) | High levels of cTn were associated with the risk of death from cardiovascular causes, myocardial infarction, stroke or heart failure | +++ | |
High levels of cTn were associated with the severity and progression of chronic heart failure | [97] | |||
Osteopontin | High osteopontin levels were associated with left ventricular dysfunction and reduced levels were correlated with good response to heart failure therapies | + | [98] | |
ST2 receptor | High ST2 levels were associated with cardiovascular mortality in chronic heart failure patients | + | [99] | |
Growth differentiator 15 (GDF-15) | High GDF-15 levels were associated with risk of developing CVD and mortality | + | [100] |