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Fig. 6 | Journal of Biomedical Science

Fig. 6

From: Pinin protects astrocytes from cell death after acute ischemic stroke via maintenance of mitochondrial anti-apoptotic and bioenergetics functions

Fig. 6

Effects of treatment with Pnn specific siRNA (si-Pnn) or control nonspecific siRNA (si-Ctrl) on cell proliferation measured by the WST-1 assay (a), LDH leakage (b), and fold changes relative to si-Ctrl group of cellular ATP level (c) in rat primary astrocytes under normoxic conditions, after 24 h of exposure to oxygen-glucose deprivation (OGD), or after 24 h of re-oxygenation (OGD/R). Values are mean ± SEM of 3–4 independent experiments. *P < 0.05 versus normoxic control (Ctrl) group, +P < 0.05 versus OGD group, and #P < 0.05 versus nonspecific siRNA group (si-Ctrl) in the post hoc Scheffé multiple-range analysis

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