Fig. 1
From: Oncolytic paramyxoviruses-induced autophagy; a prudent weapon for cancer therapy
Oncolytic paramyxoviruses infect and preferentially destroy tumor cells. Following OVs replication, cancerous cells release TAA and DAMPs, both of which can be recognized by PRRs on APCs leading to the release of inflammatory cytokines. Also, mature APCs present TAAs through MHC-Ó€ to tumor-specific CD8+ T cells and thereupon, antitumor immune response leads to the lysis of tumor cells via the release of perforin, granzyme B, and IFN-gamma