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Table 1 The interactions between oncolytic paramyxoviruses and autophagy pathway

From: Oncolytic paramyxoviruses-induced autophagy; a prudent weapon for cancer therapy

Virus .

Proteins induce autophagy

Cell/Tumor model

Autophagy/ ICD induction

Citation (s)

Newcastle disease virus

NP/P

U251

LC3-I to LC3- II conversion

Meng et al. (2012)

CEF, DF-1

LC3-I to LC3- II conversion

Sun et al. (2014) [72]

A549 resistant to cisplatin

PI3K/Akt/mTOR/p70S6K pathway

Jiang et al. (2014) [73]

Lung cancer stem cells (CSCs)

Degradation of (LC3) II and P62 proteins, inhibition of the AKT/mTOR pathway

Hu et al. (2015) [74]

GL261

Calreticulin surface exposure, the release of HMGB1 and increase in PMEL17 cancer antigen expression.

Koks et al. (2014) [79]

A549, H1650, H460

Induction of secreted HMGB1 and HSP70/90 release.

Ye et al. (2018) [78]

Measles virus

C/N

NSCLC

NSCLC

Triggering SQSTM1/p62-mediated mitophagy

Xia et al. (2014) [84]

Hela

Induction of autophagy through cellular receptor CD46 and the scaffold protein GOPC

Richetta et al. (2013) [41]

Sendai virus

NA

NSCLC, Hela, A549

Triggering autophagy through the PI3K/Akt/mTOR/p70S6K pathway

Zhang (2015) [88] and Wang (2018) [89] et al.

PC3

Triggering autophagy through the JNK, p38, and PI3K/beclin-1 pathway

Miao et al. (2018) [89]

Calu-3

Induced necrosis

Zhirnov [90]

morbillivirus

NA

Vero

Vps34/beclin1 autophagic complex

Delpeut et al. (2012) [35]

  1. NSCLC non-small cell lung cancer, PC3 human prostate cancer cell line, Calu-3 human lung cancer cell line, NP/P nucleocapsid protein/ phosphoprotein, C/N non-structural C/ nucleocapsid protein, NA not available