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Fig. 2 | Journal of Biomedical Science

Fig. 2

From: Activation of TrkB/Akt signaling by a TrkB receptor agonist improves long-term histological and functional outcomes in experimental intracerebral hemorrhage

Fig. 2

Activation of TrkB by 7,8-DHF treatment reduced brain tissue loss, neuronal damage and apoptosis after ICH. Representative cresyl violet-stained images and quantitative data of a brain atrophy ratio at 28 days; b hemorrhagic injury volume and hemispheric enlargement ratio at 3 day post-ICH. The scale bar is 2 mm. c Representative FJB-stained images and quantitative data of degenerating neurons at 3 days post-ICH. The inset is a representative FJB-positive cell at higher magnification. The scale bar is 100 μm. d Representative images of TUNEL (green) and DAPI (blue) stainings and quantitative data of apoptotic cells at 3 days post-ICH. The scale bar is 100 μm. e Representative immunoblots and quantitative data of cleaved caspase-3 levels were performed at 3 days after ICH. Values are mean ± S.E.M; **P < 0.01 and ***P < 0.001 vs. sham group; #P < 0.05 and ###P < 0.001 vs. vehicle group (n = 6 mice / group, Student’s t-test for histology and one-way ANOVA for Western blot). DHF20: 20 mg/kg 7,8-dihydroxyflavone; DHF40: 40 mg/kg 7,8-dihydroxyflavone; cCP-3: cleaved caspase-3

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