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Fig. 3 | Journal of Biomedical Science

Fig. 3

From: Activation of TrkB/Akt signaling by a TrkB receptor agonist improves long-term histological and functional outcomes in experimental intracerebral hemorrhage

Fig. 3

Activation of TrkB by 7,8-DHF treatment activated TrkB and downstream PI3K/Akt signaling, but did not affect Erk signaling after ICH. Representative immunoblots and quantitative data of a TrkB, b Akt and c Erk phosphorylation and total protein expression at 1 day and 3 days post-ICH. Values are mean ± S.E.M; *P < 0.05 vs. sham group; #P < 0.05, ##P < 0.01 and ###P < 0.001 vs. vehicle group (n = 6–7 mice / group, one-way ANOVA). Representative images of double immunostaining and quantitative data of d pTrkB-positive neurons and e pAkt Ser473-positive neurons in the peri-hematomal area at 3 days post-ICH. pTrkB or pAkt Ser473 is shown in green, and NeuN (neurons) is shown in red. Sections were stained with DAPI (blue) to show all nuclei. Values are mean ± S.E.M; ##P < 0.01 vs. vehicle group (n = 6–8 mice / group, Student’s t-test). DHF40: 40 mg/kg 7,8-dihydroxyflavone

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