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Fig. 4 | Journal of Biomedical Science

Fig. 4

From: Activation of TrkB/Akt signaling by a TrkB receptor agonist improves long-term histological and functional outcomes in experimental intracerebral hemorrhage

Fig. 4

Activation of TrkB by 7,8-DHF treatment enhanced phosphorylation of Ask-1 Ser967 and FOXO-1 but did not affect the release of mitochondrial inner proteins into the cytosol after ICH. Representative immunoblots and quantitative data of a CytoC, b Smac/DIABLO, c mitochondrial Bcl-2 and Bax ratio, d Ask-1 Ser967 phosphorylation, e FOXO-1 phosphorylation and f XIAP levels at 1 day and 3 days post-ICH. Values are mean ± S.E.M; *P < 0.05, **P < 0.01 and ***P < 0.001 vs. sham group; #P < 0.05 and ##P < 0.01 vs. vehicle group (n = 6 mice / group, one-way ANOVA). DHF40: 40 mg/kg 7,8-dihydroxyflavone

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