Skip to main content
Fig. 6 | Journal of Biomedical Science

Fig. 6

From: Activation of TrkB/Akt signaling by a TrkB receptor agonist improves long-term histological and functional outcomes in experimental intracerebral hemorrhage

Fig. 6

Delayed post-injury administration of 7,8-DHF reduced brain damage and neuronal death after ICH. a BDNF protein levels measured by ELISA at 1 day and 3 days post-ICH. Values are mean ± S.E.M; *P < 0.05 and **P < 0.01 vs. sham group; ##P < 0.01 vs. vehicle group (n = 5–7 mice/group, one-way ANOVA). Representative images of double immunostaining and quantitative data of b BDNF-positive neurons (NeuN) and c BDNF-positive astrocyte (GFAP) at 1 day post-ICH. BDNF is shown in green, and NeuN or GFAP is shown in red. Values are mean ± S.E.M; #P < 0.05 vs. vehicle group (n = 6 mice / group, Student’s t-test). Treatment of 7,8-DHF was initiated at 3 h after ICH induction. d Representative cresyl violet-stained images and quantitative data of hemorrhagic injury volume and hemispheric enlargement ratio at 3 days post-ICH. The scale bar is 2 mm. e Representative FJB-stained images and quantitative data of degenerating neurons at 3 days post-ICH. Values are mean ± S.E.M; #P < 0.05 and ##P < 0.01 vs. vehicle group (n = 6 mice / group, Student’s t-test). DHF40: 40 mg/kg 7,8-dihydroxyflavone, + 3 h: treatment initiated at 3 h post-ICH

Back to article page