Fig. 4From: Atherosclerosis and flow: roles of epigenetic modulation in vascular endotheliumSchematic diagram of regulatory machinery for modulating atherosclerosis. Atheroprotective PS induces the expression, nuclear accumulation, and association of RARα (director) and RXRα (enhancer) to promote RARα/RARE binding and miR-10a expression in ECs. PS-induced miR-10a targets pro-inflammatory transcription factor GATA6 to repress its expression to inhibit downstream VCAM-1 expression. PS-induced RARα/miR-10a signaling elicits anti-inflammatory signaling in ECs. In contrast, pro-atherogenic OS induces the association of RARα with HDAC-3/− 5/− 7 (repressors) to repress RARα-directed miR-10a signaling to induce pro-inflammatory responses in ECsBack to article page