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Table 1 Roles of HDACs in hemodynamics-modulated endothelial function and dysfunction

From: Atherosclerosis and flow: roles of epigenetic modulation in vascular endothelium

  HDACs Class Localization Affected molecule EC dysfunction/function Ref
Pro-atherogenic OS HDAC-1↑ I Nucleus↑ Nrf2 (deacetylation)/NQO1↓ Oxidation 48
    CyclinA ↑ /p21↓ Proliferation 48
HDAC-2↑ I Nucleus↑ Nrf2 (deacetylation)/NQO1↓ Oxidation 48
    CyclinA ↑ /p21↓ Proliferation 48
HDAC-3↑ I Nucleus↑ Nrf2 (deacetylation)/NQO1↓ Oxidation 48
    CyclinA ↑ /p21↓ Proliferation 48
    AKT (phosphorylation) Survival 42
HDAC-4↑ II Nucleus↑ MEF2 (deacetylation)/KLF2 ↑ VCAM ↓ Inflammation 48
HDAC-5↑ II Nucleus↑ MEF2 (deacetylation)/KLF2 ↓ VCAM↑ Inflammation 48
HDAC-7↑ II Nucleus↑ MEF2 (deacetylation)/KLF2 ↑ VCAM↓ Inflammation 48
Atheroprotective PS HDAC-1 I Nucleus/Cytosol p53 (deacetylation)/p21↑ Antiproliferation 46
HDAC-3 I Nucleus/Cytosol MEF2 (acetylation)/KLF2 ↑ VCAM↓ Anti-inflammation 48
   ? p53 (deacetylation)/p21↑ Differentiation into ECs 47
HDAC-5 II Cytosol↑ MEF2 (acetylation)/KLF2 ↑ VCAM↓ Anti-inflammation 48
    MEF2 (acetylation)/KLF2 ↑ eNOS ↑ NO production 50
HDAC-6↑ II Cytosol↑ α-tubulin Migration 51
HDAC-7 II Cytosol↑ MEF2 (acetylation)/KLF2 ↑ VCAM↓ Anti-inflammation 48
Sirt1↑ III ? eNOS (deacetylation) NO production 52