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Table 3 Roles of DNMTs in hemodynamics-modulated endothelial function and dysfunction

From: Atherosclerosis and flow: roles of epigenetic modulation in vascular endothelium

  DNMTs Target Affected molecule EC dysfunction/function Ref
Pro-atherogenic OS DNMT3a↑ KLF4↓ MCP-1↑ Inflammation 124
   Thrombomodulin↓ Inflammation 124
   NOS3↓ NO repression 124
DNMT1↑ HoxA5↓ Monocyte adhesion-related genes↑ Inflammation 125
  ? VCAM-1↑ Inflammation 127
  ? ICAM-1↑ Inflammation 127
  CTGF↑ Monocyte adhesion-related genes↑ Inflammation 127
  ? PCNA↑ Proliferation 127
  CyclinA↑ ? Proliferation 127