Table 3 Roles of DNMTs in hemodynamics-modulated endothelial function and dysfunction
From: Atherosclerosis and flow: roles of epigenetic modulation in vascular endothelium
| Â | DNMTs | Target | Affected molecule | EC dysfunction/function | Ref |
|---|---|---|---|---|---|
Pro-atherogenic OS | DNMT3a↑ | KLF4↓ | MCP-1↑ | Inflammation | 124 |
|  |  | Thrombomodulin↓ | Inflammation | 124 | |
|  |  | NOS3↓ | NO repression | 124 | |
DNMT1↑ | HoxA5↓ | Monocyte adhesion-related genes↑ | Inflammation | 125 | |
|  | ? | VCAM-1↑ | Inflammation | 127 | |
|  | ? | ICAM-1↑ | Inflammation | 127 | |
|  | CTGF↑ | Monocyte adhesion-related genes↑ | Inflammation | 127 | |
|  | ? | PCNA↑ | Proliferation | 127 | |
|  | CyclinA↑ | ? | Proliferation | 127 |