From: Atherosclerosis and flow: roles of epigenetic modulation in vascular endothelium
DNMTs | Target | Affected molecule | EC dysfunction/function | Ref | |
---|---|---|---|---|---|
Pro-atherogenic OS | DNMT3a↑ | KLF4↓ | MCP-1↑ | Inflammation | 124 |
Thrombomodulin↓ | Inflammation | 124 | |||
NOS3↓ | NO repression | 124 | |||
DNMT1↑ | HoxA5↓ | Monocyte adhesion-related genes↑ | Inflammation | 125 | |
? | VCAM-1↑ | Inflammation | 127 | ||
? | ICAM-1↑ | Inflammation | 127 | ||
CTGF↑ | Monocyte adhesion-related genes↑ | Inflammation | 127 | ||
? | PCNA↑ | Proliferation | 127 | ||
CyclinA↑ | ? | Proliferation | 127 |