Fig. 1
Effects of long-term treatment with raloxifene on ovariectomy-induced obesity in rats. a Plasma E2 level, (b) time-course changes of body weight, and (c) total visceral fat pad mass were measured after raloxifene treatment for 8 weeks. Data are expressed as mean ± SEM. *P < 0.05 versus Sham; # P < 0.05 versus OVX; +P < 0.05 versus OVX + CMC; ϕP < 0.05 versus OVX + E2, n = 8–10. OVX: ovariectomy; RAL: raloxifene (1 mg/kg/day, gavage); E2 (50 μg/kg, s.c.); CMC: carboxymethylcellulose (1 ml/kg/day, gavage)