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Fig. 7 | Journal of Biomedical Science

Fig. 7

From: Penfluridol triggers cytoprotective autophagy and cellular apoptosis through ROS induction and activation of the PP2A-modulated MAPK pathway in acute myeloid leukemia with different FLT3 statuses

Fig. 7

A working model shows the molecular mechanism underlying the ability of penfluridol to induce apoptotic cell death of acute myeloid leukemia (AML) cells. The antileukemic effect of penfluridol was attributed to its induction of caspase-mediated apoptosis via protein phosphatase 2A (PP2A)-mediated deactivation of Akt, extracellular signal-regulated kinase (ERK), and c-Jun N-terminal kinase (JNK). Meanwhile, penfluridol not only triggers apoptosis but also induces ROS-mediated autophagy. The ROS-mediated autophagy induced by penfluridol may have been due to a cell-derived protective effect against the toxic effects of penfluridol. Bold dashed lines indicate hypothetical pathways which might be regulated by penfluridol

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