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Fig. 1 | Journal of Biomedical Science

Fig. 1

From: Regulatory mechanisms of B cell responses and the implication in B cell-related diseases

Fig. 1

The action of miRNAs and key transcription factors in coordinately directing plasma cell differentiation. Several factors are involved in the negative regulation of PRDM1 in mature B cells, including BCL6/BACH2/FOXP1 and the miR-101-3p, miR-125b-5p, miR-223-3p miRNA hub. During B cell activation, NF-κB induces not only PRDM1 for the initiation of plasma cell differentiation, but also the miR-34a-5p, miR-148a-3p, miR-183-5p and miR-365a-5p hub. The induced miRNA hub including miR-34a-5p, miR-148a-3p, miR-183-5p and miR-365a-5p downregulates BCL6/BACH2/FOXP1, thereby establishing elevated levels of PRDM1 for driving plasma cell differentiation. Induced PRDM1 in turn suppresses the expression of the miR-101-3p, miR-222-3p and miR-223-3p hub, and BCL6/BACH2/FOXP1, resulting in commitment to the plasma cell fate. Lines with arrow and bars indicate upregulation and downregulation, respectively. miRNAs in a red or green box represent upregulated or downregulated expression, respectively

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